Meeting 2010

Second International Calcium Channel Conference

Placencia, Belize – March 28 to April 3, 2010

Program

Sunday, March 28:

Welcome Reception

 

Keynote lecture

William Catterall, PhD – “Calcium Channel Regulation in Synaptic Plasticity and the Fight-or-Flight Response”

 

Monday, March 29:

Calcium channel physiology

 

Terrance Snutch, PhD – “Calcium-dependent modulation of P/Q-type calcium channels is altered by Familial Hemiplegic Migraine Type-1 mutations and in a Cav2.1 splice-dependent manner”

Daniela Pietrobon, PhD – “Differential effect of hemiplegic migraine mutations in the P/Q-type Ca2+ channel on cortical excitatory and inhibitory synaptic transmission”

Hee-Sup Shin, PhD – “Observational fear learning by empathy involves affective pain system and Cav1.2 Ca2+ channels in the anterior cingulate cortex”

Emmanuel Bourinet, PhD – “Direct functional coupling between the CaV3.2 T-type calcium channel and nitric oxide synthase contributes to nociception”

Paula Barrett, PhD – “Spontaneous electrical firing of mouse adrenal zona glomerulosa cells: role of Cav3.2 channels.”

Peter Stys, MD – “Internodal Ca permeable channels: implications for axonal degeneration”

Leanne Cribbs, PhD – “Regulation of T-type Calcium Channels in Pulmonary Hypertension and Ventricular Remodeling”

Ricardo Dolmetsch, PhD – “Using iPSC derived neurons to study the cellular basis of Timothy syndrome, a multisystemic disorder associated with autism”

 

Tuesday, March 30:

Calcium channel interactions/regulation

 

Gerald Zamponi, PhD – “Regulation of calcium channels by the ERAD complex”

Daniel Minor, PhD – “Structural and functional investigation of multiple Ca2+/CaM binding sites on the Cav1.2 C‑terminal tail uncovers a role in channel facilitation and no evidence for dimer formation”

Annette Dolphin, PhD – “Calcium channel α2δ subunits: GPI-anchoring, trafficking and mechanism of action of gabapentinoid drugs”

Ray Turner, PhD – “Cav3 calcium channels link to the Kv4 channel complex to control neuronal output”

Emilio Carbone, PhD – “Role of Cav1.3 and fast inactivating BK channel coupling in pacemaking mouse chromaffin cells”

Kevin Currie, PhD – “Activity-dependent inhibition of N-type calcium channels: a novel PKC-independent effect of phorbol esters”

 

Wednesday, March 31:

Calcium channel gating

 

Kurt Beam, PhD – “Voltage- and calcium-dependent inactivation of Cav1.2, but not of Cav2.1, is suppressed in skeletal muscle”

Stefan Herzig, PhD – “Single channel manifestations of L-type calcium channel inactivation”

Steffen Hering, PhD – “Gating determinants in L-type (CaV1.2) channels”

Alexandra Koschak, PhD – “Impact of protein interactions for gating modulation of Cav 1.3 L-type calcium channels”

Edward Perez-Reyes, PhD – “Characterization of the gating brake in the I-II loop of CaV3 T-type Ca2+ channels”

Slobodan Todorovic, MD, PhD – “Glycosylation alters gating and inactivation of T-type calcium channels in the pain pathway”

 

Thursday, April 1:

Gene transcription and posttranslational modification

 

Diane Lipscombe, PhD – “Cell-specific alternative splicing in N-type calcium channels controls their sensitivity to G protein coupled receptors”

Tuck Wah Soong, PhD – “Post-transcriptional modification modulates CaV channel function”

Zhong-Ping Feng, PhD – “Gene expression and functional L-type calcium channel”

Data Blitz:

Stuart Cain (Cav3.2 + burst firing in GAERS); Summer Allen (Fox-2 and N-type splice regulation); Laura Roberts (β subunit control of localization); Thomas Helton (Microtubule proteins and N-type); Osvaldo Uchitel (FHM-1 and Cav 2.1)

Reception & Dinner

 

Friday, April 2:

Pharmacology

 

Osvaldo Uchitel, PhD – “Intrinsic activation/inactivation parameters of CaV2.1 calcium channels are shifted by Pregabalin, modulating neurotransmitter release”

Elizabeth Tringham, PhD – “Novel T-type blockers identified in CaV3.2 state-dependent fluorescent assay effectively suppress seizures”

Z. David Luo, PhD – “Mechanism of calcium channel α2δ-1  subunit mediated neuropathic pain”

 

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