Second International Calcium Channel Conference

Placencia, Belize – March 28 to April 3, 2010

Abstracts

Keynote

Catterall – Calcium Channel Regulation in Synaptic Plasticity and the Fight-or-Flight Responsedo

Calcium channel physiology

Snutch – Calcium-dependent modulation of PQ-type calcium channels is altered by Familial Hemiplegic Migraine Type-1 mutations and in a Cav2.1 splice-dependent manner

Pietrobon – Differential effect of hemiplegic migraine mutations in the PQ-type Ca2+ channel on cortical excitatory and inhibitory synaptic transmission

Shin – Observational fear learning by empathy involves affective pain system and Cav1.2 Ca2+ channels in the anterior cingulate cortex

Bourinet – Direct functional coupling between the CaV3.2 T-type calcium channel and nitric oxide synthase contributes to nociception

Barrett – Spontaneous electrical firing of mouse adrenal zona glomerulosa cells role of Cav3.2 channels

Stys – Internodal Ca permeable channels implications for axon degeneration

Cribbs – Regulation of T-type Calcium Channels in Pulmonary Hypertension and Ventricular Remodeling

Dolmetsch – Using iPSC derived neurons to study the cellular basis of Timothy syndrome, a multisystemic disorder associated with autism

Calcium channel interactions/regulation

Zamponi – Regulation of calcium channels by the ERAD complex

Minor – Structural and functional investigation of multiple Ca2+CaM binding sites on the CaV1.2 C terminal tail uncovers a role in channel facilitation and no evidence for dimer formation

Dolphin – Calcium channel α2δ subunits GPI-anchoring, trafficking and mechanism of action of gabapentinoid drugs

Turner – Cav3 calcium channels link to the Kv4 channel complex to control neuronal output

Carbone – Role of Cav1.3 and fast inactivating BK channel coupling in pacemaking mouse chromaffin cells

Currie – Activity-dependent inhibition of N-type calcium channels a novel PKC-independent effect of phorbol esters

Calcium channel gating

Beam – Voltage- and calcium-dependent inactivation of Cav1.2, but not of Cav2.1, is suppressed in skeletal muscle

Herzig – Single channel manifestations of L-type calcium channel inactivation

Hering – Gating determinants in L-type (CaV1.2) channels

Koschak – Impact of protein interactions for gating modulation of CaV1.3 L-type calcium channels

Perez-Reyes – Characterization of the gating brake in the I-II loop of CaV3 T-type Ca2+ channels

Todorovic – Glycosylation alters gating and inactivation of T-type calcium channels in the pain pathway

Gene transcription and posttranslational modification

Lipscombe – Cell-specific alternative splicing in N-type calcium channels controls their sensitivity to G protein coupled receptors

Soong – Post-transcriptional modification modulates CaV channel function

Feng – Gene expression and functional L-type calcium channel regulation

Pharmacology

Uchitel – Intrinsic activationinactivation parameters of CaV2.1 calcium channels are shifted by Pregabalin, modulating neurotransmitter release

Tringham – Novel T-type blockers identified in CaV3.2 state-dependent fluorescent assay effectively suppress seizures

Luo – Mechanism of calcium channel α2δ-1 subunit mediated neuropathic pain

Data Blitz

Cain – Increased Rate of Recovery from Inactivation in CaV3.2 T-type Calcium Channels Promotes Robust Neuronal Burst Firing During Oscillations in a Rat Absence Epilepsy Model

Allen – The splicing factor Fox-2 controls N-type calcium channel activity in sympathetic neurons

Roberts – Cav β subunit N- and C-terminal variable domains roles in N-type (Cav2.2) channel localisation

Helton – The microtubule destabilizing protein stathmin-2 interacts with CaV2.2 N-type channels

Uchitel – Gain of function in FHM-1 Cav2.1 knock-in mice is related to the shape of the action potential