| Sunday Feb 25 | |
|---|---|
| Snutch / Zamponi | Opening Remarks |
| Diane Lipscombe | Plenary lecture 1: Calcium Ion Channels: Forms and Functions |
| Hee Sup Shin | Plenary lecture 2: Neurobiology of observational fear in rodents, a model for affective empathy |
| Monday Feb 26: | |
|---|---|
| Disease Mechanisms: | |
| Anjali Rajadhyaksha | Altered mRNA translation drives social deficits in a mouse model of Cacna1c (Cav1.2) deficiency |
| Dick Tsien | Brain disorders, evolution and noncoding regions of calcium channel genes |
| Nadine Ortner | CACNA1D (Cav1.3) variants in human disease: from molecular mechanisms to therapeutic approaches |
| Geoffrey Pitt | Multiple Extrapancreatic Mechanisms Drive Hypoglycemia in Timothy Syndrome |
| Birgit Liss | Cav channels, dopamine neurons and Parkinson's disease |
| Melanie Mark | Cerebellar α1D-adrenergic receptors mediate stress-induced dystonia in totteringtg/tg mice |
| Norbert Weiss | T-type calcium channels in amyotrophic lateral sclerosis |
| Petronel Tuluc | CaV1.3 L-type calcium channel regulates pancreatic β-cell mass, electrical activity, and insulin release. |
| Cardiovascular: | |
| Steffen Hering | Assay for evaluation of proarrhythmic effects of herbal products |
| Kelvin Loh | Trainee talk: Modulating CaV1.2 though Galectin-3 — A novel therapeutic pathway for blood pressure management |
| Jing Zhai | Trainee talk: Modulation of RNA editing of CaV1.3 channels: Implications in circadian rhythm and feeding |
| Tuesday Feb 27: | |
|---|---|
| Cardiovascular (cntd): | |
| Bill Caterall | Convergent Regulation of Cardiac Cav1.2 Channels |
| Livia Hool | Mechanosensing the stiff myocardium in an in vitro model of hypertrophic cardiomyopathy |
| Ivy Dick | Diverse pathogenic mechanisms underlying calcium channelopathies |
| Matteo Mangoni | L-type Cav1.3 (alpha1D) and ‘funny’ f-(HCN) channels underpin heart rate acceleration by catecholamines |
| Michael Netzer | Trainee talk: Multi-chamber cardioids unravel human heart development and cardiac defects |
| Liu Cong | Trainee talk: RNA editing and oxygen-sensing mediated Filamin A-CaV1.2 interaction in the progress of hypertension |
| Pain: | |
| Slobodan Todorovic | Trace metal modulation of Cav3.2 channels in pain pathways: Can we actually teach an old dog new tricks? |
| Michael Hildebrand | Expression of calcium channel subtypes in rodent and human spinal pain processing circuits |
| Jin Tao | Epigenetic regulation of trigeminal-mediated neuropathic pain |
| David Luo | Validation of a pain target involving calcium channel alpha-2-delta-1 subunit proteins |
| Emmanuel Bourinet | From mice to humans: T-type channels in peripheral and spinal circuits |
| Wednesday Feb 28: | |
|---|---|
| Pain (cntd): | |
| Mike Salter | Degeneracy in spinal pain signaling |
| Robert Bonin | Reversal of pathological pain through calcium-dependent and independent signalling of spinal NMDA receptors |
| Atsufumi Kawabata | Distinct modulation of Cav3.2 function by sulfide and polysulfide |
| Henry Colecraft | A tale of two queens: Cav channels and ubiquitin |
| Toto Olivera | Differential Expression of Ca Channel Isoforms in Specific Types of Sensory Neurons: Implications for Pain |
| Laurent Ferron | Trainee talk: Functional remodeling of presynaptic voltage-gated calcium channels in nociceptor central terminals during neuropathic pain |
| Robin Stringer | Trainee talk: Development of novel non-opioid calcium channel antagonists for pain therapeutics |
| Synapses, circuits and plasticity: | |
| Valentina Di Biase | L-type channels in dendritic growth of hippocampal neurons |
| Gerald Obermair | α2δ proteins in synaptic functions and brain disorders |
| Stefan Herlitze | Modulation of ion channels and synaptic plasticity by OptoXRs |
| Thursday Feb 29: | |
|---|---|
| Synapses, circuits and plasticity (cntd): | |
| Erick Hernandez Ochoa | S100A1-stimulated activation of PKA augments CaV1.3 currents in a Rad-dependent manner in a heterologous expression system |
| Martin Heine | Be in time, connecting molecular dynamics to synaptic function |
| Roger Thompson | Metabotropic NMDAR LTD requires pannexin-1 and P2X4 |
| Brian MacVicar | Calcium channels and calcium signaling in glia |
| Luyang Wang | The impact of calcium-dependent facilitation of calcium currents on presynaptic plasticity |
| Modulation: | |
| Byung-Chang Suh | Molecular basis for PIP2 regulation of CaV2.2 channel |
| Mary Horne | Potentiation of neuronal CaV1.2 activity by alpha1-adrenergic receptor signaling through PKC, Pyk2 and Src |
| Johannes Hell | Regulation of the L-type Ca channel Cav1.2 in neurons |
| Bozhidar Baltov | Trainee talk: New chip technology for studying the effects of ion channel blockers on stem cell derived myocardial cells |
| Noelia Jacobo Piqueras | Trainee talk: Molecular mechanisms responsible for the sex differences in pancreatic β-cell electrical activity and insulin release |
| Stephanie Geisler | Trainee talk: Genetic deletion of Stac2 adaptor protein alters electrical activity of mouse chromaffin cells |
| Friday March 1: | |
|---|---|
| Modulation (ctnd): | |
| Manu Ben Johny | Engineering genetically encoded actuators of L-type Ca channels |
| Structure and function: | |
| Jian Yang | Conformational landscape of activation of a Ca2+-permeable channel by its natural ligand |
| Filip van Petegem | Where calcium channels meet: structures of calcium-selective channels at ER:PM junctions |
| Bernhard Flucher | How four structurally and functionally distinct voltage sensors control calcium channel properties and functions? |
| Philippe Lory | Be sure your calcium channels gates lucky |
| Marta Campiglio | Molecular mechanisms of multiple STAC interactions in voltage-gated calcium channel modulation and function |
| Adriano Senatore | Evolving Excitation - Placozoans and the origins of calcium channel and neurotransmitter receptor function |
| Hugo Bibollet | Trainee talk: Cav1.1 Voltage Sensors Tracking through Functional Site-Directed Fluorometry in Muscle Fibe |
| Yousra El Galeb | Trainee talk: Structural variants of the gate, selectivity filter and voltage sensors determining the function and dysfunction of T-type calcium channels |
| Ferenc Torok | Trainmee talk: Mutation-induced changes in channel gating parameters increase sensitivity of pathogenic Cav1.3 L-type Ca2+ channel variants towards Ca2+ channel blocker isradipine |
| Daniel Minor | Assembling the electrosome - a first structural look at CaV biogenesis |
| Snutch / Zamponi | Closing Remarks |