Meeting Agenda

Sunday Feb 25
Snutch / ZamponiOpening Remarks
Diane LipscombePlenary lecture 1: Calcium Ion Channels: Forms and Functions
Hee Sup ShinPlenary lecture 2: Neurobiology of observational fear in rodents, a model for affective empathy

Monday Feb 26:
Disease Mechanisms:
Anjali RajadhyakshaAltered mRNA translation drives social deficits in a mouse model of Cacna1c (Cav1.2) deficiency
Dick TsienBrain disorders, evolution and noncoding regions of calcium channel genes
Nadine OrtnerCACNA1D (Cav1.3) variants in human disease: from molecular mechanisms to therapeutic approaches
Geoffrey PittMultiple Extrapancreatic Mechanisms Drive Hypoglycemia in Timothy Syndrome
Birgit LissCav channels, dopamine neurons and Parkinson's disease
Melanie MarkCerebellar α1D-adrenergic receptors mediate stress-induced dystonia in totteringtg/tg mice
Norbert WeissT-type calcium channels in amyotrophic lateral sclerosis
Petronel TulucCaV1.3 L-type calcium channel regulates pancreatic β-cell mass, electrical activity, and insulin release.
Steffen HeringAssay for evaluation of proarrhythmic effects of herbal products
Kelvin LohTrainee talk: Modulating CaV1.2 though Galectin-3 — A novel therapeutic pathway for blood pressure management
Jing ZhaiTrainee talk: Modulation of RNA editing of CaV1.3 channels: Implications in circadian rhythm and feeding

Tuesday Feb 27:
Cardiovascular (cntd):
Bill CaterallConvergent Regulation of Cardiac Cav1.2 Channels
Livia HoolMechanosensing the stiff myocardium in an in vitro model of hypertrophic cardiomyopathy
Ivy DickDiverse pathogenic mechanisms underlying calcium channelopathies
Matteo MangoniL-type Cav1.3 (alpha1D) and ‘funny’ f-(HCN) channels underpin heart rate acceleration by catecholamines
Michael NetzerTrainee talk: Multi-chamber cardioids unravel human heart development and cardiac defects
Liu CongTrainee talk: RNA editing and oxygen-sensing mediated Filamin A-CaV1.2 interaction in the progress of hypertension
Slobodan TodorovicTrace metal modulation of Cav3.2 channels in pain pathways: Can we actually teach an old dog new tricks?
Michael HildebrandExpression of calcium channel subtypes in rodent and human spinal pain processing circuits
Jin TaoEpigenetic regulation of trigeminal-mediated neuropathic pain
David LuoValidation of a pain target involving calcium channel alpha-2-delta-1 subunit proteins
Emmanuel BourinetFrom mice to humans: T-type channels in peripheral and spinal circuits

Wednesday Feb 28:
Pain (cntd):
Mike SalterDegeneracy in spinal pain signaling
Robert BoninReversal of pathological pain through calcium-dependent and independent signalling of spinal NMDA receptors
Atsufumi KawabataDistinct modulation of Cav3.2 function by sulfide and polysulfide
Henry ColecraftA tale of two queens: Cav channels and ubiquitin
Toto OliveraDifferential Expression of Ca Channel Isoforms in Specific Types of Sensory Neurons: Implications for Pain
Laurent FerronTrainee talk: Functional remodeling of presynaptic voltage-gated calcium channels in nociceptor central terminals during neuropathic pain
Robin StringerTrainee talk: Development of novel non-opioid calcium channel antagonists for pain therapeutics
Synapses, circuits and plasticity:
Valentina Di BiaseL-type channels in dendritic growth of hippocampal neurons
Gerald Obermairα2δ proteins in synaptic functions and brain disorders
Stefan HerlitzeModulation of ion channels and synaptic plasticity by OptoXRs

Thursday Feb 29:
Synapses, circuits and plasticity (cntd):
Erick Hernandez OchoaS100A1-stimulated activation of PKA augments CaV1.3 currents in a Rad-dependent manner in a heterologous expression system
Martin HeineBe in time, connecting molecular dynamics to synaptic function
Roger ThompsonMetabotropic NMDAR LTD requires pannexin-1 and P2X4
Brian MacVicarCalcium channels and calcium signaling in glia
Luyang WangThe impact of calcium-dependent facilitation of calcium currents on presynaptic plasticity
Byung-Chang SuhMolecular basis for PIP2 regulation of CaV2.2 channel
Mary HornePotentiation of neuronal CaV1.2 activity by alpha1-adrenergic receptor signaling through PKC, Pyk2 and Src
Johannes HellRegulation of the L-type Ca channel Cav1.2 in neurons
Bozhidar BaltovTrainee talk: New chip technology for studying the effects of ion channel blockers on stem cell derived myocardial cells
Noelia Jacobo PiquerasTrainee talk: Molecular mechanisms responsible for the sex differences in pancreatic β-cell electrical activity and insulin release
Stephanie GeislerTrainee talk: Genetic deletion of Stac2 adaptor protein alters electrical activity of mouse chromaffin cells

Friday March 1:
Modulation (ctnd):
Manu Ben JohnyEngineering genetically encoded actuators of L-type Ca channels
Structure and function:
Jian YangConformational landscape of activation of a Ca2+-permeable channel by its natural ligand
Filip van PetegemWhere calcium channels meet: structures of calcium-selective channels at ER:PM junctions
Bernhard FlucherHow four structurally and functionally distinct voltage sensors control calcium channel properties and functions?
Philippe LoryBe sure your calcium channels gates lucky
Marta CampiglioMolecular mechanisms of multiple STAC interactions in voltage-gated calcium channel modulation and function
Adriano SenatoreEvolving Excitation - Placozoans and the origins of calcium channel and neurotransmitter receptor function
Hugo BibolletTrainee talk: Cav1.1 Voltage Sensors Tracking through Functional Site-Directed Fluorometry in Muscle Fibe
Yousra El GalebTrainee talk: Structural variants of the gate, selectivity filter and voltage sensors determining the function and dysfunction of T-type calcium channels
Ferenc TorokTrainmee talk: Mutation-induced changes in channel gating parameters increase sensitivity of pathogenic Cav1.3 L-type Ca2+ channel variants towards Ca2+ channel blocker isradipine
Daniel MinorAssembling the electrosome - a first structural look at CaV biogenesis
Snutch / ZamponiClosing Remarks